Guia Adenomiose

REFERÊNCIAS BIBLIOGRÁFICAS

  • Bazot M, Cortez A, Darai E, Rouger J, Chopier J, Antoine JM, Uzan S. Ultrasonography compared with magnetic resonance imaging for the diagnosis of adenomyosis: correlation with histopathology. Hum Reprod. 2001 Nov;16(11):2427-33.
  • Bazot M, Darai E, Hourani R, Thomassin I, Cortez A, Uzan S, Buy JN. Deep pelvic endometriosis: MR imaging for diagnosis and prediction of extension of disease. Radiology. 2004 Aug;232(2):379-89.
  • Benagiano G, Habiba M, Brosens I. The pathophysiology of uterine adenomyosis: an update. Fertil Steril. 2012 Sep;98(3):572-9.
  • Brosens I, Robertson WB, Dixon HG. The physiological response of the vessels of the placental bed to normal pregnancy. J Pathol Bacteriol. 1967 Apr;93(2):569-79.
  • Brosens IA, Robertson WB, Dixon HG 1972 The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu. 1972;1:177-91.
  • Brosens JJ, Barker FG, de Souza NM 1998 Myometrial zonal differentiation and uterine junctional zone hyperplasia in the non-pregnant uterus. Hum Reprod Update. 1998 Sep-Oct;4(5):496-502.
  • Brosens JJ, de Souza NM, Barker FG. Uterine junctional zone: function and disease. Lancet. 1995 Aug 26;346(8974):558-60.
  • Campo S, Campo V, Benagiano G. Adenomyosis and infertility. Reprod Biomed Online. 2012 Jan;24(1):35-46.
  • Campo S, Campo V, Benagiano G. Infertility and adenomyosis. Obstet Gynecol Int. 2012;2012:786132
  • Cao Y, Zhuang MF, Yang Y, Xie SW, Cui JG, Cao L, Zhang TT, Zhu Y. Preliminary study of quercetin affecting the hypothalamic-pituitary-gonadal axis on rat endometriosis model. Evid Based Complement Alternat Med. 2014;2014:781684.
  • Chen Y, Chen C, Shi S, Han J, Wang J, Hu J, Liu Y, Cai Z, Yu C. Endometriotic implants regress in rat models treated with puerarin by decreasing estradiol level. Reprod Sci. 2011 Sep;18(9):886-91.
  • Chen Y, Zhu B, Zhang H, Ding D, Liu X, Guo SW. Possible Loss of GABAergic Inhibition in Mice With Induced Adenomyosis and Treatment With Epigallocatechin-3-Gallate Attenuates the Loss With Improved Hyperalgesia. Reprod Sci. 2014 Feb 3;21(7):869-882.
  • Chen Y, Zhu B, Zhang H, Liu X, Guo SW. Epigallocatechin-3-gallate reduces myometrial infiltration, uterine hyperactivity, and stress levels and alleviates generalized hyperalgesia in mice induced with adenomyosis. Reprod Sci. 2013 Dec;20(12):1478-91.
  • Cockerham AZ. Adenomyosis: a challenge in clinical gynecology. J Midwifery Womens Health. 2012 May-Jun;57(3):212-20.
  • Cohen I, Beyth Y, Tepper R, Figer A, Shapira J, Cordoba M, Yigael D, Altaras MM. Adenomyosis in postmenopausal breast cancer patients treated with tamoxifen: a new entity? Gynecol Oncol. 1995 Jul;58(1):86-91.
  • Costello MF, Lindsay K, McNally G. The effect of adenomyosis on in vitro fertilisation and intra-cytoplasmic sperm injection treatment outcome. Eur J Obstet Gynecol Reprod Biol. 2011 Oct;158(2):229-34.
  • de Souza NM, Brosens JJ, Schwieso JE, Paraschos T, Winston RM. The potential value of magnetic resonance imaging in infertility. Clin Radiol. 1995 Feb;50(2):75-9.
  • de Vries K, Lyons EA, Ballard G Levi CS, Lindsay DJ. Contractions of the inner third of the myometrium. Am J Obstet Gynecol. 1990 Mar;162(3):679-82.
  • Di Spiezio Sardo A, Guida M, Bettocchi S, Nappi L, Sorrentino F, Bifulco G, Nappi C. Role of hysteroscopy in evaluating chronic pelvic pain. Fertil Steril. 2008 Oct;90(4):1191-6.
  • Dim CC, Agu PU, Dim NR, Ikeme AC. Adenomyosis and uterine rupture during labour in a primigravida: an unusual obstetric emergency in Nigeria. Trop Doct. 2009 Oct;39(4):250-1.
  • Dong X, Yang Z. High-intensity focused ultrasound ablation of uterine localized adenomyosis. Curr Opin Obstet Gynecol. 2010 Aug;22(4):326-30.
  • Donnez J, Nisolle M, Casanas-Roux F, Bassil S, Anaf V. Rectovaginal septum, endometriosis or adenomyosis: laparoscopic management in a series of 231 patients. Hum Reprod. 1995 Mar;10(3):630-5.
  • Dueholm M. Transvaginal ultrasound for diagnosis of adenomyosis: a review. Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20(4):569-82.
  • Dueholm M, Lundorf E, Hansen ES, Sørensen JS, Ledertoug S, Olesen F. Magnetic resonance imaging and transvaginal ultrasonography for the diagnosis of adenomyosis. Fertil Steril. 2001 Sep;76(3):588-94.
  • Fedele L, Bianchi S, Frontino G. Hormonal treatments for adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2008 Apr;22(2):333-9.
  • Fedele L, Bianchi S, Raffaelli R, Portuese A, Dorta M. Treatment of adenomyosis-associated menorrhagia with a levonorgestrel-releasing intrauterine device. Fertil Steril. 1997 Sep;68(3):426-9.
  • Fischer CP, Kayisili U, Taylor HS. HOXA10 expression is decreased in endometrium of women with adenomyosis. Fertil Steril. 2011 Mar 1;95(3):1133-6.
  • Gordts S, Brosens JJ, Fusi L, Benagiano G, Brosens I. Uterine adenomyosis: a need for uniform terminology and consensus classification. Reprod Biomed Online. 2008 Aug;17(2):244-8.
  • Greaves P, White IN. Experimental adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20(4):503-10.
  • Grimbizis GF, Mikos T, Tarlatzis B. Uterus-sparing operative treatment for adenomyosis. Fertil Steril. 2014 Feb;101(2):472-87.
  • Hauth EA, Jaeger HJ, Libera H, Lange S, Forsting M. MR imaging of the uterus and cervix in healthy women: determination of normal values. Eur Radiol. 2007 Mar;17(3):734-42.
  • Hricak H, Alpers C, Crooks LE, Sheldon PE. Magnetic resonance imaging of the female pelvis: initial experience. AJR Am J Roentgenol. 1983 Dec;141(6):1119-28.
  • Huang BS, Seow KM, Tsui KH, Huang CY, Lu YF, Wang PH. Fertility outcome of infertile women with adenomyosis treated with the combination of a conservative microsurgical technique and GnRH agonist: long-term follow-up in a series of nine patients. Taiwan J Obstet Gynecol. 2012 Jun;51(2):212-6.
  • Igarashi M, Abe Y, Fukuda M, Ando A, Miyasaka M, Yoshida M, Shawki OA. Novel conservative medical therapy for uterine adenomyosis with a danazol-loaded intrauterine device. Fertil Steril. 2000 Aug;74(2):412-3.
  • Jana S, Rudra DS, Paul S, Snehasikta S. Curcumin delays endometriosis development by inhibiting MMP-2 activity. Indian J Biochem Biophys. 2012 Oct;49(5):342-8.
  • Ji M, Liu Y, Yang S, Zhai D, Zhang D, Bai L, Wang Z, Yu J, Yu C, Cai Z. Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen receptor-α. J Steroid Biochem Mol Biol. 2013 Nov;138:421-6.
  • Juang CM, Chou P, Yen MS, Twu NF, Horng HC, Hsu WL. Adenomyosis and risk of preterm delivery. BJOG. 2007 Feb;114(2):165-9.
  • Kamada Y, Nakatsuka M, Asagiri K, Noguchi S, Habara T, Takata M, Kudo T. GnRH agonist-suppressed expression of nitric oxide synthases and generation of peroxynitrite in adenomyosis. Hum Reprod. 2000 Dec;15(12):2512-9.
  • Khong TY, De Wolf F, Robertson WB, Brosens. Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol. 1986 Oct;93(10):1049-59.
  • Kido A, Togashi K, Nakai, A, Kataoka ML, Koyama T, Fujii S. Oral contraceptives and uterine peristalsis: evaluation with MRI. J Magn Reson Imaging. 2005 Aug;22(2):265-70.
  • Kido A, Togashi K, Nishino M, Miyake K, Koyama T, Fujimoto R, Iwasaku K, Fujii S, Hayakawa K. Cine MR imaging of uterine peristalsis in patients with endometriosis. Eur Radiol. 2007 Jul;17(7):1813-9.
  • Kim KH, Lee EN, Park JK, Lee JR, Kim JH, Choi HJ, Kim BS, Lee HW, Lee KS, Yoon S. Curcumin attenuates TNF-α-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells. Phytother Res. 2012 Jul;26(7):1037-47.
  • Kim MD, Kim NK, Kim HJ, Lee MH. Pregnancy following uterine artery embolization with polyvinyl alcohol particles for patients with uterine fibroid or adenomyosis. Cardiovasc Intervent Radiol. 2005 Sep-Oct;28(5):611-5.
  • Kishi Y, Suginami H, Kuramori R, Yabuta M, Suginami R, Taniguchi F. Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification. Am J Obstet Gynecol. 2012 Aug;207(2):114.e1-7
  • Kissler S, Hamscho N, Zangos S, Wiegratz I, Schlichter S, Menzel C, Doebert N, Gruenwald F, Vogl TJ, Gaetje R, Rody A, Siebzehnruebl E, Kunz G, Leyendecker G, Kaufmann M. Uterotubal transport disorder in adenomyosis and endometriosis--a cause for infertility. BJOG. 2006 Aug;113(8):902-8.
  • Kissler S, Zangos S, Wiegratz I, Kohl J, Rody A, Gaetje R, Doebert N, Wildt L, Kunz G, Leyendecker G, Kaufmann M. Utero-tubal sperm transport and its impairment in endometriosis and adenomyosis. Ann N Y Acad Sci. 2007 Apr;1101:38-48.
  • Kitajima K, Imanaka K, Kuwata Y, Hashimoto K, Sugimura K. Magnetic resonance imaging of typical polypoid adenomyoma of the uterus in 8 patients: correlation with pathological findings. J Comput Assist Tomogr. 2007 May-Jun;31(3):463-8.
  • Kitawaki J. Adenomyosis: the pathophysiology of an oestrogen-dependent disease. Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20(4):493-502
  • Kunz G, Beil D, Huppert P, Noe M, Kissler S, Leyendecker G. Adenomyosis in endometriosis – prevalence and impact on fertility. Evidence from magnetic resonance imaging. Hum Reprod. 2005 Aug;20(8):2309-16.
  • Kunz G, Beil D, Huppert P, Leyendecker G. Oxytocin – a stimulator of directed sperm transport in humans. Reprod Biomed Online. 2007 Jan;14(1):32-9.
  • Kunz G, Herbertz M, Beil D, Huppert P, Leyendecker G. Adenomyosis as a disorder of the early and late human reproductive period. Reprod Biomed Online. 2007 Dec;15(6):681-5.
  • Kunz G, Leyendecker G 2002 Uterine peristaltic activity during the menstrual cycle: characterization, regulation, function and dysfunction. Reprod Biomed Online. 2002;4 Suppl 3:5-9.
  • Levy G, Dehaene A, Laurent N, Lernout M, Collinet P, Lucot JP, Lions C, Poncelet E. An update on adenomyosis. Diagn Interv Imaging. 2013 Jan;94(1):3-25.
  • Leyendecker G, Herbertz M, Kunz G, Mall G 2002 Endometriosis results from the dislocation of basal endometrium. Hum Reprod. 2002 Oct;17(10):2725-36.
  • Leyendecker G, Kunz G, Herbertz M, Beil D, Huppert P, Mall G, Kissler S, Noe M, Wildt L.
  • Uterine peristaltic activity and the development of endometriosis. Ann N Y Acad Sci. 2004 Dec;1034:338-55.
  • Leyendecker G, Kunz G, Kissler S, Wildt L. Adenomyosis and reproduction. Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20(4):523-46.
  • Lin J, Sun C, Zheng H. Gonadotropin-releasing hormone agonists and laparoscopy in the treatment of adenomyosis with infertility. Chin Med J (Engl). 2000 May;113(5):442-5.
  • Liu X, Guo SW. Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis. J Obstet Gynaecol Res. 2011 Jul;37(7):696-708.
  • Lyons EA, Taylor PJ, Zheng XH, Ballard G, Levi CS, Kredentser JV. Characterization of subendometrial, myometrial contractions throughout the menstrual cycle in normal fertile women. Fertil Steril. 1991 Apr;55(4):771-4.
  • Maheshwari A, Gurunath S, Fatima F, Bhattacharya S. Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes. Hum Reprod Update. 2012 Jul;18(4):374-92.
  • Mao X, Wang Y, Carter AV, Zhen X, Guo SW. The retardation of myometrial infiltration, reduction of uterine contractility, and alleviation of generalized hyperalgesia in mice with induced adenomyosis by levo-tetrahydropalmatine (l-THP) and andrographolide. Reprod Sci. 2011 Oct;18(10):1025-37.
  • Mark AS, Hricak H, Heinrichs LW, Hendrickson MR, Winkler ML, Bachica JA, Stickler JE. Adenomyosis and leiomyoma: differential diagnosis with MR imaging. Radiology. 1987 May;163(2):527-9.
  • Martinez-Conejero JA, Morgan M, Montesinos M, Fortuno S, Meseguer M, Simon C, Horcajadas JA, Pellicer A. Adenomyosis does not affect implantation, but is associated with miscarriage in patients undergoing oocyte donation. Fertil Steril. 2011 Oct;96(4):943-50.
  • McCarthy S, Tauber C, Gore J. Female pelvic anatomy: MR assessment of variations during the menstrual cycle and with use of oral contraceptives. Radiology. 1986 Jul;160(1):119-23.
  • McCausland V, McCausland A. The response of adenomyosis to endometrial ablation/resection. Hum Reprod Update. 1998 Jul-Aug;4(4):350-9.
  • Mehasseb MK, Bell SC, Pringle JH, Habiba MA. Uterine adenomyosis is associated with ultrastructural features of altered contractility in the inner myometrium. Fertil Steril. 2010 May 1;93(7):2130-6.
  • Mehasseb MK, Panchal R, Taylor AH, Brown L, Bell SC, Habiba M. Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis. Fertil Steril. 2011 Jun;95(7):2228-35, 2235.e1.
  • Meredith SM, Sanchez-Ramos L, Kaunitz AM. Diagnostic accuracy of transvaginal sonography for the diagnosis of adenomyosis: systematic review and metaanalysis. Am J Obstet Gynecol. 2009 Jul;201(1):107.e1-6.
  • Mijatovic V, Florijn E, Halim N, Schats R, Hompes P. Adenomyosis has no adverse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI. Eur J Obstet Gynecol Reprod Biol. 2010 Jul;151(1):62-5.
  • Naftalin J, Hoo W, Pateman K, Mavrelos D, Holland T, Jurkovic D. How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum Reprod. 2012 Dec;27(12):3432-9.
  • Nikolaou M, Kourea HP, Antonopoulos K, Geronatsiou K, Adonakis G, Decavalas G. Spontaneous uterine rupture in a primigravid woman in the early third trimester attributed to adenomyosis: a case report and review of the literature. J Obstet Gynaecol Res. 2013 Mar;39(3):727-32.
  • Nishida M, Takano K, Arai Y, Ozone H, Ichikawa R. Conservative surgical management for diffuse uterine adenomyosis. Fertil Steril. 2010 Jul;94(2):715-9.
  • Noe M, Kunz G, Herbertz M, Mall G, Leyendecker G. The cyclic pattern of the immunocytochemical expression of oestrogen and progesterone receptors in human myometrial and endometrial layers: characterization of the endometrial–subendometrial unit. Hum Reprod. 1999 Jan;14(1):190-7.
  • Osada H, Silber S, Kakinuma T, Nagaishi M, Kato K, Kato O. Surgical procedure to conserve the uterus for future pregnancy in patients suffering from massive adenomyosis. Reprod Biomed Online. 2011 Jan;22(1):94-9.
  • Ostrzenski A 1998 Extensive iatrogenic adenomyosis after laparoscopic myomectomy. Fertil Steril. 1998 Jan;69(1):143-5.
  • Ota H, Igarashi S, Hatazawa J, Tanaka T. Is adenomyosis an immune disease? Hum Reprod Update. 1998 Jul-Aug;4(4):360-7.
  • Parott E, Butterworth M, Green A, White IN, Greaves P. Adenomyosis: a result of disordered stromal differentiation. Am J Pathol. 2001 Aug;159(2):623-30.
  • Peric H, Fraser IS. The symptomatology of adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20(4):547-55.
  • Pijnenborg R, Dixon G, Robertson WB, Brosens I. Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy. Placenta. 1980 Jan-Mar;1(1):3-19.
  • Protopapas A, Milingos S, Markaki S, Loutradis D, Haidopoulos D, Sotiropoulou M, Antsaklis A. Cystic uterine tumors. Gynecol Obstet Invest. 2008;65(4):275-80.
  • Rabinovici J, Inbar Y, Eylon SC, Schiff E, Hananel A, Freundlich D. Pregnancy and live birth after focused ultrasound surgery for symptomatic focal adenomyosis: a case report. Hum Reprod. 2006 May;21(5):1255-9.
  • Rabinovici J, Stewart EA. New interventional techniques for adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20(4):617-36.
  • Reinhold C, McCarthy S, Bret PM, Mehio A, Atri M, Zakarian R, Glaude Y, Liang L, Seymour RJ. Diffuse adenomyosis: comparison of endovaginal US and MR imaging with histopathologic correlation. Radiology. 1996 Apr;199(1):151-8.
  • Reinhold C, Tafazoli F, Wang L. Imaging features of adenomyosis. Hum Reprod Update. 1998 Jul-Aug;4(4):337-49.
  • Riggs JC, Lim EK, Liang D, Bullwinkel R. Cesarean section as a risk factor for the development of adenomyosis uteri. J Reprod Med. 2014 Jan-Feb;59(1-2):20-4.
  • Salamanca A, Beltran E. Subendometrial contractility in menstrual phase visualized by transvaginal sonography in patients with endometriosis. Fertil Steril. 1995 Jul;64(1):193-5.
  • Salim R, Riris S, Saab W, Abramov B, Khadum I, Serhal P. Adenomyosis reduces pregnancy rates in infertile women undergoing IVF. Reprod Biomed Online. 2012 Sep;25(3):273-7.
  • Schindl M, Birner P, Obermair A, Kiesel L, Wenzl R. Increased microvessel density in adenomyosis uteri. Fertil Steril. 2001 Jan;75(1):131-5.
  • Takeda A, Sakai K, Mitsui T, Nakamura H. Laparoscopic management of juvenile cystic adenomyoma of the uterus: report of two cases and review of the literature. J Minim Invasive Gynecol. 2007 May-Jun;14(3):370-4.
  • Takeuchi H, Kitade M, Kikuchi I, Shimanuki H, Kumakiri J, Kitano T, Kinoshita K. Laparoscopic adenomyomectomy and hysteroplasty: a novel method. J Minim Invasive Gynecol. 2006 Mar-Apr;13(2):150-4.
  • Tamai K, Koyama T, Umeoka S, Saga T, Fujii S, Togashi K. Spectrum of MR features in adenomyosis. Best practice and research. Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20(4):583-602.
  • Tamai K, Togashi K, Ito T, Morisawa N, Fujiwara T, Koyama T. MR Imaging findings of adenomyosis: correlation with histopathologic features and diagnostic pitfalls. Radiographics. 2005 Jan-Feb;25(1):21-40.
  • Thalluri V, Tremellen KP. Ultrasound diagnosed adenomyosis has a negative impact on successful implantation following GnRH antagonist IVF treatment. Hum Reprod. 2012 Dec;27(12):3487-92.
  • Tremellen KP, Russell P. The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. II: adenomyosis and macrophages. J Reprod Immunol. 2012 Jan;93(1):58-63.
  • Turnbull LW, Rice CF, Horsman A, Robinson J, Killick SR. Magnetic resonance imaging and transvaginal ultrasound of the uterus prior to embryo transfer. Hum Reprod. 1994 Dec;9(12):2438-43.
  • Vercellini P, Vigano P, Somigliana E, Daguati R, Abbiati A, Fedele L. Adenomyosis: epidemiological factors. Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20(4):465-77.
  • Wang PH, Su WH, Sheu BC, Liu WM. Adenomyosis and its variance: adenomyoma and female fertility. Taiwan J Obstet Gynecol. 2009 Sep;48(3):232-8.
  • Weiss G, Maseelall P, Schott LL, Brockwell SE, Schocken M, Johnston JM. Adenomyosis a variant, not a disease? Evidence from hysterectomized menopausal women in the Study of Women's Health Across the Nation (SWAN). Fertil Steril. 2009 Jan;91(1):201-6.
  • Wiczyk HP, Janus CL, Richards CJ, Graf MJ, Gendal ES, Rabinowitz JG, Laufer N. Comparison of magnetic resonance imaging and ultrasound in evaluating follicular and endometrial development throughout the normal cycle. Fertil Steril. 1988 Jun;49(6):969-72.
  • Woodfield CA, Siegelman ES, Coleman BG, Torigian DA. CT features of adenomyosis. Eur J Radiol. 2009 Dec;72(3):464-9.
  • Xavier P, Beires J, Barros H, Martinez-de-Oliveira J 2005 subendometrial and intra-endometrial blood flow during the menstrual cycle in patients with endometriosis. Fertil Steril. 2005 Jul;84(1):52-9.
  • Xishi Liu, Lei Yuan, Guo SW. Valproic acid as a therapy for adenomyosis: a comparative case series. Reprod Sci. 2010 Oct;17(10):904-12.
  • Yang Z, Cao YD, Hu LN, Wang ZB. Feasibility of laparoscopic high-intensity focused ultrasound treatment for patients with uterine localized adenomyosis. Fertil Steril. 2009 Jun;91(6):2338-43.
  • Yu J, Zhao L, Zhang D, Zhai D, Shen W, Bai L, Liu Y, Cai Z, Li J, Yu C. The effects and possible mechanisms of puerarin to treat endometriosis model rats. Evid Based Complement Alternat Med. 2015;2015:269138.
  • Yuen PM. Adenomyosis following endometrial rollerball ablation. Aust N Z J Obstet Gynaecol. 1995 Aug;35(3):335-6.
  • Zhang Y, Cao H, Yu Z, Peng HY, Zhang CJ. Curcumin inhibits endometriosis endometrial cells by reducing estradiol production. Iran J Reprod Med. 2013 May;11(5):415-22.
  • Zhu B, Chen Y, Zhang H, Liu X, Guo SW. Resveratrol Reduces Myometrial Infiltration, Uterine Hyperactivity, and Stress Levels and Alleviates Generalized Hyperalgesia in Mice With Induced Adenomyosis. Reprod Sci. 2015 Feb 20. pii: 1933719115572479.

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